Bacillus S-Layer-Mediated Innate Interactions During Endophthalmitis
نویسندگان
چکیده
منابع مشابه
Bacillus cereus endophthalmitis.
Endophthalmitis, of any aetiology, is a potentially devastating ocular infection. Few patients are able to maintain good visual acuity. Many retain only navigational vision and a significant number require evisceration or enucleation. 2 The incidence ofendophthalmitis after trauma has been estimated to occur in 2-7% of cases.3 Various organisms have been implicated but, in recent years, Bacillu...
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PURPOSE Bacillus endophthalmitis is a highly explosive infection of the eye that commonly results in rapid inflammation and vision loss, if not loss of the eye itself, within a few days. Quorum-sensing-controlled toxins are essential to virulence during infection. Another unique characteristic of this disease is the ability of Bacillus to replicate rapidly and migrate to all parts of the eye. T...
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Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known about the effect of anthrax on the immune function of neutrophils, a key frontline effector of innate immune defense. Here we showed that deplet...
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UNLABELLED Bacillus anthracis vegetative forms assemble an S-layer comprised of two S-layer proteins, Sap and EA1. A hallmark of S-layer proteins are their C-terminal crystallization domains, which assemble into a crystalline lattice once these polypeptides are deposited on the bacterial surface via association between their N-terminal S-layer homology domains and the secondary cell wall polysa...
متن کاملToward improving therapeutic regimens for Bacillus endophthalmitis.
PURPOSE Bacillus cereus causes the most virulent and refractory form of endophthalmitis. The authors analyzed the effectiveness of early treatment with vancomycin or gatifloxacin, with or without dexamethasone, for experimental B. cereus endophthalmitis. METHODS Rabbit eyes were injected intravitreally with 100 colony-forming units of B. cereus. At 2, 4, or 6 hours after infection, eyes were ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00215